As you have only one day,  let us focus on the prominent offbeat attractions including California Academy of Sciences.

The California Academy of Sciences is one of the largest science museums of natural history in the world. It was established in 1853, with an intention of conducting research activities. This attraction happens to be the only complex in the world, which features a research center, a planetarium, an aquarium and an archive of natural history under one roof. It exhibits around 38,000 wild animals as well as aquatic creatures. Its major highlight is its Living Roof, which is a splendid example of modern technology.

 (Source: Nathan Jongewaard)

A review:

Awesome place!! Give yourself plenty of time to see everything. We were there for 4 hours and we still didn't see all of it. The planetarium was awesome!  So many creatures of the sea and on land. The living roof was just ok. I thought it would be prettier but it was just plain ugly. The aquarium was so cool! I really liked the exhibit of the Philippine coral reefs. Try to watch some of the shows. We were only able to watch one- ssssnake exhibit.

 (Source: California Academy of Sciences - San Francisco, CA)

Address: 55 Music Concourse Dr.

Contact No:             (415) 379-8000     

Open: Mon to Sat 9:30am-5pm; Sun 11am-5pm

Admission Fees: $2

After exploring the academy, it's now time for lunch. The A16 can be an ideal place to satisfy your taste buds. It's a popular Italian diner, flaunting Neapolitan-style interior, mouth-watering cuisine, and great service. This diner flaunts a spacious dining hall, an open kitchen and a bar.  Make sure to order for meatballs.

Review by a guest:

My favorite place to eat in San Francisco. The burratta cheese starter is simply phenomenal. I've never been so googly-eyed over cheese in my life. This deliciously creamy cheese is amazing. The pizza here is very savory.  I love the fresh ingredients and how they blend together with the thin crust.  Definitely a favorite.  

 (Source: A 16 - Marina/Cow Hollow - San Francisco, CA)

Address: 2355 Chestnut Street

Contact no:             (415) 771-2216     

Cuisine: Italian

Open: Wed to Fri 11:30am-2:30pm; Sun to Thu 5pm-10pm; Fri to Sat 5pm-11pm

Prices: Main course starts from $10

 (Source: Wolfgang Jung)

After this head on to the The Cartoon Art Museum which is one of the most offbeat attraction in San Francisco as not everyone would like to venture out to this place until and unless you are a hardcore cartoon fanatic. This extraordinary place is dedicated to the art of comics and cartoons that we have all been subjected to as a child.

This unique museum was founded in 1985 by a group of comic art enthusiasts and this is the only museum in the whole of Western United States dedicated to the preservation and exhibition of all forms of cartoon art. The permanent collection features some 6,000 pieces, including original animation cels, comic book pages and early newspaper comic strips.

(Source: permanently scatterbrained)

 A review:

It is small. That said, it had a wonderful collection of original cartoon art. We loved the political cartoons and took a trip down memory lane with the Disney ones. Go to the website for current exhibit info as they apparently shuffle it around pretty regularly. Worth the $6 and the 1 hour it will take to see it!

 (Source: Cartoon Art Museum Reviews – 10 Reviews of Cartoon Art Museum - TripAdvisor)

In the end do not miss the De Young Museum.  It's the city's oldest art museum, founded in 1895. After undergoing renovation, it was reopened in 2005. It flaunts a myriad of exquisite art collections, including American paintings, sculptures, decorative exhibits, African Art, Oceanic Art, Contemporary Crafts etc.

Address: 50 Hagiwara Tea Garden Dr.

Contact No:             +1 415 863 3330     

Open: Tue to Sun 9:30am-5:15pm; Fri 9:30am-8:45pm

Admission Fees: $10

After this end your day with a nice dinner at On day 2, the popular House of Prime Rib, which is located near Washington Station. The dining room is cozy yet elegant, boasting fireplaces and an authentic cuisine. The menu has some interesting names such as the King Henry VIII cut, English cut, etc.

(Source: bryce_edwards)

Address: 1906 Van Ness Ave.

Contact No:             415/885-4605     

Cuisine: American

Open: Daily 10am-10pm

Hope the above information was of help to you.

In case you need any further information about anything else  in San Francisco then please feel free to write back to us.

Have a nice day.

Regards

Chitwan